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Conversion of aromatic aldehydes into nitriles via N-tosylimines

โœ Scribed by Richard S. Glass; Richard C. Hoy


Publisher
Elsevier Science
Year
1976
Tongue
French
Weight
112 KB
Volume
17
Category
Article
ISSN
0040-4039

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Ab~mrt: O-Arylcarbamoylated hydroxylamine tosylate reacts with aldehydes at room temperature to give the corresponding O-earbamoylated oximes. The reaction of earbamoylated hydroxylamine with aromatic aldehydes in THF or in toluene at reflux affords the corresponding nitriles and anilinium tosylate

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The synthesis of nitriles is a process which, in the past, has frequently required quite n vigorous reaction conditions'. In recent years, however, interest has arisen in examining milder methods for nitrile synthesis 3-5 . As a contribution to the solution of this problem of reaction conditions, w