Conversion of alcohols to bromides using a fluorous phosphine
โ Scribed by Laurence Desmaris; Nathalie Percina; Louis Cottier; Denis Sinou
- Book ID
- 108284706
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 181 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The conversion of primary and secondary alcohols to chlorides and bromides using 1,2-bis(diphenylphosphino)ethane (diphos) is described. Use of this reagent in lieu of the typical triphenylphosphine-carbontetrahalide complex provides a facile means of purifying the desired halide from the phosphine-
A useful conversion of alcohols to alkyl fluorides via their fluoroformates is introduced. The fluoroformates are obtained in nearly quantitative yield from the alcohols by treatment with COF 2 (generated in situ from bis(trichloromethyl) carbonate) in ether with KF as an added acid scavenger. The n