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Conversion of 4,6-disubstituted pyrimidines into 1,2,4-Triazoles by action of Hydrazine

✍ Scribed by H. C. van der Plas; H. Jongejan

Book ID
104587928
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
320 KB
Volume
89
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

4,6‐Diethoxy‐, 4‐ethoxy‐6‐hydrazino‐, 4,6‐dichloro‐, 4,6‐di(methylthio)‐and 4,6‐dihydrazinopyrimidine react with aqueous hydrazine at 210° to give 3‐methyl‐1,2,4‐triazole. Evidence is presented that in this unprecedented ring contraction reaction the C(2)‐N(3 or 1)‐C(4 or 6)‐C(5) fragment of the pyrimidine ring is involved in the formation of this 1,2,4‐triazole.

📜 SIMILAR VOLUMES

Addition of hydrazine to 4,7-dihydro[1,2
Addition of hydrazine to 4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidines: Hydrazine derivatives of 4,5,6,7-tetrahydro[1,2,4]triazolo[1,5-a]pyrimidine
✍ Sergey A. Komykhov; Konstantin S. Ostras; Kyryl M. Kobzar; Vladimir I. Musatov; 📂 Article 📅 2009 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 63 KB

## Abstract magnified image The 7‐aryl‐4,7‐dihydro[1,2,4]triazolo[1,5‐__a__]pyrimidines **1a**, **1b**, **1c** can undergo addition of hydrazine to the enamine double bond leading to hydrazine derivatives of tetrahydrotriazolopyrimidines **2a**, **2b**, **2c**; the process is usually accompanied by

ChemInform Abstract: Addition of Hydrazi
ChemInform Abstract: Addition of Hydrazine to 4,7-Dihydro[1,2,4]triazolo[1,5-a]pyrimidines: Hydrazine Derivatives of 4,5,6,7-Tetrahydro[1,2,4]triazolo[1,5-a]pyrimidine.
✍ Sergey A. Komykhov; Konstantin S. Ostras; Kyryl M. Kobzar; Vladimir I. Musatov; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v