The dopamine hypothesis of schizophrenia proposed that dopaminergic pathways are involved in the etiology of the disease. In particular, interest among psychiatrists has focused on the D, receptor because of its affinity to antipsychotic drugs. Recently a new dopamine receptor gene has been cloned,
Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia
β Scribed by Fuquan Zhang; Hua Fan; Yong Xu; Kerang Zhang; Xuezhu Huang; Yan Zhu; Manqiu Sui; Gaoxiang Sun; Kun Feng; Bo Xu; Xiaoqian Zhang; Zhonghua Su; Chunqing Peng; Pozi Liu
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 651 KB
- Volume
- 156
- Category
- Article
- ISSN
- 1552-4841
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## Abstract We have reported an association between schizophrenia and homozygosity of a Bal I polymorphism in the first exon of the dopamine D3 receptor gene (Crocq et al.: __Journal of Medical Genetics__ 29:858β860, 1992). The present study consists of an attempt to replicate this finding in a fur
There is considerable controversy regarding a putative association between schizophrenia and a biallelic BalI polymorphism in the first exon of the dopamine D3 receptor gene (DRD3), although meta-analyses of published data suggest an association. If such an association exists, it may be detectable a