Convergent total synthesis of epolactaene: application of bridgehead oxiranyl anion strategy

✍ Scribed by Kouji Kuramochi; Seigo Nagata; Hideyoshi Itaya; Ken-ichi Takao; Susumu Kobayashi

• Book ID: 104262293
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 224 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)01512-9

✦ Synopsis

Total synthesis of (+)-epolactaene was accomplished by a convergent approach utilizing the fluoride anioncatalyzed aldol-type reaction of (-)-ot-trimethylsilylangelica lactone epoxide with tetraene aldehyde as a key reaction.