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Convergent synthesis of the tetracyclic bcde structural fragment of retigeranic acid

✍ Scribed by A. L. Veretenov; A. S. Gybin; V. A. Smit

Book ID
112448966
Publisher
Springer
Year
1990
Tongue
English
Weight
210 KB
Volume
39
Category
Article
ISSN
1573-9171

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The synthesis of the BCDE-tetracyclic core of (-)-cephalotaxine has been achieved in eight steps starting from N-Boc-L-proline methyl ester. An alkylidene carbene 1,5-CH insertion reaction was used as a key step in the stereocontrolled synthesis of the DE-spirocyclic fragment and an intramolecular H