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Convergent stereospecific total synthesis of Monocillin I and Monorden (or Radicicol)

✍ Scribed by Maxime Lampilas; Robert Lett


Book ID
108380017
Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
188 KB
Volume
33
Category
Article
ISSN
0040-4039

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Convergent stereospecific total synthesi
✍ Isabelle Tichkowsky; Robert Lett πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 304 KB

A much improved and reliable access to the macrolide 9, key-intermediate in our synthesis of monocillin I and radicicol is reported, via a modification of our first synthesis. The formation of the conjugated E,Z-dienone trans-epoxide is now achieved in a much higher yield, in a stereospecific reacti