Convergent Solid Phase Peptide Synthesis: An Efficient Approach to the Synthesis of Highly Repetitive Protein Domains
β Scribed by Dalcol, Ionara; Rabanal, Francesc; Ludevid, Maria-Dolors; Albericio, Fernando; Giralt, Ernest
- Book ID
- 121208844
- Publisher
- American Chemical Society
- Year
- 1995
- Tongue
- English
- Weight
- 850 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
In the synthesis of large peptides or proteins, highly homogeneous segments are indispensable for a convergent strategy either on a solid-phase resin or in solution. Employing Boc/Bzl chemistry to prepare fully protected segments with a free h-carboxyl group from the solid support, base-labile linke
## Abstract The RING finger domain of the Mdm2, located at the __C__βterminus of the protein, is necessary for regulation of p53, a tumor suppressor protein. The 48βresidues long Mdm2 peptide is an important target for studying its interaction with small anticancer drug candidates. For the chemical