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Convenient Transformation of Optically Active Nitroalkanes into Chiral Aldoximes and Nitriles

โœ Scribed by Constantin Czekelius; Erick M. Carreira


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
110 KB
Volume
44
Category
Article
ISSN
0044-8249

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โœ Kusch, Dirk ;Montforts, Franz-Peter ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 430 KB

The oxazaborolidine (g)-catalyzed reduction of acetylporphyrins (4) led to enantiomerically pure hydroxyethylporphyrins (5), which were transformed into optically active chlorin derivatives (7 and 8 ) upon reaction by N,N-dimethylacetamide dimethyl acetal followed by hydrogenation. The absolute conf