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Convenient synthesis of cyclopenta[c,d]pyrene and 3,4-dihydrocyclopenta[c,d]pyrene. The reactivity of the pyrene dianion

โœ Scribed by C. Tintel; J. Cornelisse; J. Lugtenburg

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
743 KB
Volume
102
Category
Article
ISSN
0165-0513

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## Abstract The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Judged by the inhibiting effect of wortmannin, phosphatidylโ€inositolโ€3 (PIโ€3) kinases su