Convenient synthesis of 5-substituted-6-methoxy or 6-hydroxy-2,3-dihydro-1,4-benzodioxins via lithiated intermediates
✍ Scribed by Thierry Besson; Mohamed Hretani; Gérard Coudert; Gérald Guillaumet
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 698 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
The 6-methoxy and 6tetrahydropyranyloxy-2,3-&hy~1,4-benxdoxms can be bthmted at the Sposmon to give mtermdate hth~o darvahves wbch react with various electrophrles to affod, after hydrolys~, S-substMed-&methoxy and 6-hydroxy-2.3~ydro-1.4-ben~oxtns
📜 SIMILAR VOLUMES
Convenient syntheses of relatively rare 2,2-disubstituted-2,3-dihydro~l,4-benzodioxins from 2-substituted-2-hydroxy-2,3-dihydro-l,4-benzodioxins, as key synthetic intermediates, are reported. These new synthetic approaches require Lewis acid BF3-Et20 mediated nucleophilic substitution reaction or cy
The preparation of a number of 2,3-dihydro-6-(hydroxyphenyl)-1,4-diazepinium salts (11 c -f) and of 1,2-dihydro-5-(hydroxyphenyl)-2-oxopyri1nidinium salts (17a, b) from 3-(hydroxypheny1)vinamidinium salts (10 b, c) is described. Attempted preparation of a 3-(2-hydroxypheny1)vinamidinium salt gave in