Convenient synthesis of 2,2-disubstituted-2,3-dihydro-1,4-benzodioxins from 2-substituted-2-hydroxy-2,3-dihydro-1,4-benzodioxins

✍ Scribed by Valérie Thiéry; Gérard Coudert; Gérald Guillaumet

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 664 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(96)01140-4

✦ Synopsis

Convenient syntheses of relatively rare 2,2-disubstituted-2,3-dihydro~l,4-benzodioxins from 2-substituted-2-hydroxy-2,3-dihydro-l,4-benzodioxins, as key synthetic intermediates, are reported. These new synthetic approaches require Lewis acid BF3-Et20 mediated nucleophilic substitution reaction or cyclization of suitable hydroxyphenols.