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Convenient syntheses of N-CD3 labelled nicotine and nicotine analogues

✍ Scribed by Jeffrey I. Seeman; Henry V. Secor; Gary Forrest

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
321 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

Two procedures for the preparation of N-CD3 labelled nicotine and nicotine analogues are reported. These include: (a) the deuteroiodomethylation of the lithium amide of the corresponding secondary m i n e ; and (b) the alkylation of the corresponding cyclic imine followed by sodium cyanoborohydride reduction of the resulting alkyl iminium salt. Products having both high chemical and isotopic purity are formed.

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