✦ LIBER ✦

The syntheses of deuterium labelled tobacco alkaloids: Nicotine, nornicotine and cotinine

✍ Scribed by Trong-Lang Nguyen; Neal Castagnoli Jr

Publisher: John Wiley and Sons
Year: 1978
Tongue: French
Weight: 501 KB
Volume: 14
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580140618

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✦ Synopsis

A v a r i e t y o f deuterium l a b e l l e d tobacco a l k a l o i d s has been prepared f o r metabolic studies. myosmine w i t h sodium borodeuteride provided n o r n i c o t i n e -2'-dl. exchange w i t h deuterium oxide t o myosmine-3',3'-d2 which could be reduced t o nornicotine-3',3'-d2 and nornicotine-2',3',3'-d3. Thus avenues t o n i c o t i n e a l k a l o i d s l a b e l l e d a t C ; , and/or C ; , have been establ i s h e d .

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