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Convenient Syntheses of 6-Methylpurine and Related Nucleosides

โœ Scribed by Hassan, Abdalla E. A.; Abou-elkair, Reham A. I.; Montgomery, John A.; Secrist, John A.


Book ID
121245251
Publisher
Taylor and Francis Group
Year
2000
Tongue
English
Weight
602 KB
Volume
19
Category
Article
ISSN
0732-8311

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LNA (Locked Nucleic Acids) is a novel oligonucleotide analogue containing [2.2.1 ]bicycle nucleoside monomers. A novel and significantly improved method for convergent synthesis of LNA [2.2.1]bicycle nucleosides using a 4-Ctosyloxymethyl-l,2-di-O-acetyl furanose as a key synthon is described. In add