An improved method for the solution-phase derivatization of Tyr 3 -Lys 5 (Dde)-octreotide (TOC(Dde)) and Tyr 3 -Lys 5 (Dde)-octreotate (TATE(Dde)) with the macrocyclic chelator DOTA (1,4,7,10-tetraazacyclododecane-N%,Nยฆ,N ยง,Nยจ-tetraacetic acid) has been developed. The fully protected parent peptides
Convenient solid-phase synthesis of Tyr3-octreotide
โ Scribed by Te-Wei Lee; Shiang-Rong Chang; Shui-Tein Chen; Zei-Tsan Tsai
- Book ID
- 108484532
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 254 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0969-8043
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## Abstract Peptides have been modified with quadruple hydrogen bonding ureidoโpyrimidinone moieties to be applied in supramolecular architectures for biomedical applications. A convenient solidโphase synthesis method was developed to functionalize peptide sequences with ureidoโpyrimidinone units.