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Convenient methods for the synthesis of d4, d2 and d6 isotopomers of 4-(4-fluorobenzyl)piperidine

✍ Scribed by Ágnes Proszenyák; Béla Ágai; Gábor Tárkányi; László Vida; Ferenc Faigl

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
112 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

Pure 4-(4-fluoro-[2,3,5,6-2 H 4 ]benzyl)piperidine was prepared via the Grignard reaction of 4-fluoro-[2,3,5,6-2 H 4 ]bromobenzene and pyridine-4-aldehyde followed by consecutive deoxygenation and heteroatomic ring saturation in the presence of palladium on carbon catalyst. An improved method for the catalytic H/D exchange in benzylic positions of 4-(4-fluorobenzyl)piperidine and its d 4 derivative has also been described.

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