Convenient enantioselective synthesis of new 1,4-sulfanylalcohols from γ-lactones

✍ Scribed by Jean-Jacques Filippi; Xavier Fernandez; Louisette Lizzani-Cuvelier; André-Michel Loiseau

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 119 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01268-6

✦ Synopsis

A synthetic strategy based upon three basic reactions-enzymatic resolution, oxygen-sulfur exchange, reductionallowed us to carry out an easy and useful synthesis of a series of new 1,4-sulfanylalcohols from aliphatic g-lactones. Final products have been obtained in good yields with enantiomeric excesses in a 66-91% range.