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Convenient Acylative Dealkylation of Tertiary Amines

✍ Scribed by Dave, Paritosh R.; Kumar, Kaipenchery A.; Duddu, Rajagopal; Axenrod, Theodore; Dai, Rongji; Das, Kajal K.; Guan, Xiao-Pei; Sun, Jianguang; Trivedi, Nirupam J.; Gilardi, Richard D.


Book ID
126075736
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
44 KB
Volume
65
Category
Article
ISSN
0022-3263

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ChemInform Abstract: Convenient Acylativ
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

The dealkylation of tertiary aliphatic a
✍ David S. Millan; Rolf H. Prager πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 174 KB

Phenyl chlorothionoformate reacts rapidly with aliphatic amines at 20Β°C to give a thiourethane and an alkyl chloride. The urethanes are readily converted to the secondary amine salt by reaction with dimethyl sulfate, followed by hydrolysis with water. Rates of reaction, and alkyl group cleavage sele