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Controversy concerning paternal age effect in 47,+21 Down's syndrome

โœ Scribed by Andrew D. Carothers

Publisher
Springer
Year
1988
Tongue
English
Weight
129 KB
Volume
78
Category
Article
ISSN
0340-6717

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Reexamination of paternal age effect in
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The recent discovery that the extra chromosome in about 30% of cases of 47, trisomy 21 is of paternal origin has revived interest in the possibility of paternal age as a risk factor for a Down syndrome birth, independent of maternal age. Parental age distribution for 611 Down's syndrome 47, +21 case

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Paternal age distribution for 1279 cases of Down's syndrome born in 1952--1968 was compared with the corresponding distribution for the general population, corrected for the maternal age as well as for the year of birth of the patients. Although there was no difference in the mean paternal age, the