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Controlling substitution patterns on the 1,2,4-triazolo[1,5-α]-pyrimidine ring. Selective removal of chlorine at the 7-position

✍ Scribed by William T. Monte; William A. Kleschick; Jon Bordner

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 445 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360127

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✦ Synopsis

A highly effective method for the selective removal of chlorine from the 7-position of the 1,2,4-triazolo[1,5-a]pyrimidine ring in the presence of chlorine at the 5 - or 6 -positions is reported. The method involves treatment of the appropriate substrate with zinc-copper couple in the presence of acetic acid in methanol-tetrahydrofuran. The method enables the construction of a variety of substitution patterns in key intermediates for the 1,2,4-triazolo[1,5-a]pyrimidine sulfonanilide herbicides.

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