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Controlling Degradation of Acid-Hydrolyzable Pluronic Hydrogels by Physical Entrapment of Poly(lactic acid-co-glycolic acid) Microspheres

✍ Scribed by Jun Bae Lee; Ki Woo Chun; Jun Jin Yoon; Tae Gwan Park

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
267 KB
Volume
4
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Summary: Chemically crosslinked biodegradable hydrogels based on di‐acrylated Pluronic F‐127 tri‐block copolymer were prepared by a photopolymerization method. Poly(lactic acid‐co‐glycolic acid) (PLGA) microspheres were physically entrapped within the Pluronic hydrogel in order to modulate the local pH environment by acidic degradation by‐products of PLGA microspheres. The PLGA microspheres were slowly degraded to create an acidic microenvironment, which facilitated the cleavage of an acid‐labile ester‐linkage in the biodegradable Pluronic hydrogel network. The presence of PLGA microspheres accelerated the degradation of the Pluronic hydrogel and enhanced the protein release rate when protein was loaded in the hydrogel.

SEM image of photo‐crosslinked Pluronic hydrogel entrapping PLGA microspheres.

magnified imageSEM image of photo‐crosslinked Pluronic hydrogel entrapping PLGA microspheres.

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