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Controlled release scaffolds for bone tissue engineering

✍ Scribed by Sarah Cartmell

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
143 KB
Volume
98
Category
Article
ISSN
0022-3549

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✦ Synopsis

Bone disease and trauma can sometimes create defects that require more than current clinical therapies can provide for effective healing. Scaffolds that release bioactive agents such as drugs offer additional benefits in this regard in comparison to those whose main requirements are space filling and load bearing. This review details a variety of recent research on scaffold carrier systems that release osteogenic drugs for orthopaedic treatment purposes. The controlled release scaffolds presented are created from a variety of materials (such as tricalcium phosphate, hydrogel systems and poly(D,L-lactide)) and release drugs such as statins, bisphosphonates and a variety of growth factors.

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