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Biodegradable poly(α-hydroxy acid) polymer scaffolds for bone tissue engineering

✍ Scribed by Nicole Y. C. Yu; Aaron Schindeler; David G. Little; Andrew J. Ruys

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
164 KB
Volume
9999B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

Synthetic graft materials are emerging as a viable alternative to autogenous bone graft and bone allograft for the treatment of critical‐sized bone defects. These materials can be osteoconductive but are rarely intrinsically osteogenic, although this can be greatly enhanced by the application of bone morphogenetic proteins (BMPs). This review will discuss the versatility of biodegradable poly(α‐hydroxy acids) for the delivery of BMPs for bone tissue engineering. Poly(α‐hydroxy acids) have a considerable potential for customization and adaptability via modification of design parameters, including scaffold architecture, composition, and biodegradability. Different fabrication techniques will also be discussed. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010

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