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Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells

✍ Scribed by Siddharth Jhunjhunwala; Stephen C. Balmert; Giorgio Raimondi; Eefje Dons; Erin E. Nichols; Angus W. Thomson; Steven R. Little


Book ID
113695029
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
1007 KB
Volume
159
Category
Article
ISSN
0168-3659

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Interleukin 2 (IL-2) is a pleotropic growth factor essential to immune system function. Current methods of administration are limited by the necessity of hospitalization as well as dose-limiting toxicities and side effects. There is also the issue of low therapeutic concentrations at the desired sit