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Controlled monohalogenation of phosphonates: A new route to pure α-monohalogenated diethyl benzylphosphonates

✍ Scribed by Bogdan Iorga; Frédéric Eymery; Philippe Savignac

Book ID: 104209243
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 981 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00037-x

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✦ Synopsis

Starting from diethyl benzylphosphonates, a wide variety of diethyl ot-monofluoro, chloro, bromo and iodobenzylphosphonates have been obtained in pure form by a one-pot procedure. This high yielding method implies the intermediate protection of the benzyl anion with TMSC1 followed by halogenation with an electrophilic halogenating reagent.

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