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Controlled Drug Release from Self-Catalyzed Poly(Ortho Esters)

โœ Scribed by STEVEN Y. NG; THIERRY VANDAMME; MICHELLE S. TAYLOR; JORGE HELLER


Book ID
111393418
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
443 KB
Volume
831
Category
Article
ISSN
0890-6564

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A polyblend of poly(ortho esters)-poly(ethylene glycol) (POE-PEG) was prepared. The release behavior of the acetanilide-loaded film of the POE-PEG polyblend was studied. Blending POE with water-soluble PEG can promote the release of drug in pH 7.4 PBS buffer at 37ยฐC, while POE has plasticizing effec

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Semisolid, self-catalyzed poly(ortho ester)s (POEs), are investigated as potential sustained-release systems for proteins. In this study, some factors influencing protein release kinetics and protein instability were evaluated. As model proteins, lysozyme, alpha-lactalbumin, bovine serum albumin, an