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Control of β-Catenin Stability: Reconstitution of the Cytoplasmic Steps of the Wnt Pathway in Xenopus Egg Extracts

✍ Scribed by Adrian Salic; Ethan Lee; Leslie Mayer; Marc W. Kirschner

Book ID
117736411
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
395 KB
Volume
5
Category
Article
ISSN
1097-2765

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## Abstract The WNT/β‐catenin pathway is involved in numerous human cancers. Mutations of the __CTNNB1__ (β‐catenin) gene have also been detected in a subset of pediatric Wilms tumors, but the target genes of the deregulated WNT/β‐catenin pathway in these tumors have yet to be identified. To compar