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Control of the Flow Properties of DNA by Topoisomerase II and Its Targeting Inhibitor

✍ Scribed by Kundukad, Binu; van der Maarel, Johan R.C.


Book ID
119207447
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
657 KB
Volume
99
Category
Article
ISSN
0006-3495

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## Abstract The sequence specificity of topoisomerase‐II‐mediated DNA cleavage, stimulated by 2‐methyl‐9‐hydroxy ellipticinium and 4β€², 5β€²,7‐trihydroyflavone (genistein) was investigated by sequencing analysis of DNA cleavage sites and molecular modeling techniques. The former drug exhibits a marked