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Control of Six Contiguous Stereocenters in an Asymmetric Organocatalytic One-Pot Michael/Michael/Aldol Addition Sequence

✍ Scribed by Dieter Enders; Gregor Urbanietz; Elisa Cassens-Sasse; Sebastian Keeß; Gerhard Raabe


Book ID
111992710
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
449 KB
Volume
354
Category
Article
ISSN
1615-4150

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Organocatalytic Asymmetric Michael Addit
✍ Yu-Hua Liao; Wen-Bing Chen; Zhi-Jun Wu; Xi-Lin Du; Lin-Feng Cun; Xiao-Mei Zhang; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB 👁 1 views

## Abstract The first organocatalytic diastereo‐ and enantioselective Michael addition reaction of 4‐substituted‐pyrazolin‐5‐ones to nitroolefins has been developed with a chiral bifunctional thiourea as organocatalyst. A wide variety of desired multi‐substituted pyrazolin‐5‐one derivatives with co