✦ LIBER ✦

Control of proliferation of bovine vascular endothelial cells

✍ Scribed by Denis Gospodarowicz; John S. Moran; Debra L. Braun

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 630 KB
Volume: 91
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040910307

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effects of Fibroblast Growth Factor (FGF) and Epidermal Growth Factor (EGF) on the proliferation of bovine vascular endothelial cells has been examined. FGF induces the initiation of DNA synthesis and cell proliferation in cloned endothelial cells of fetal and adult origin at concentrations as low as 1 ng/ml and is saturating at 50 ng/ml. EGF had no effect over the same range of concentrations. The mitogenic effect of FGF is blocked by a crude extract of cartilage. Platelet extract is also mitogenic for vascular endothelial cells although to a lesser extent than the purified FGF. In contrast to vascular endothelial cells, both EGF and FGF are mitogenic for vascular smooth muscle cells although EGF is less mitogenic than FGF at 100 ng/ml. The mitogenic effect of EGF and FGF on vascular smooth muscle is not blocked by the addition of a crude extract of cartilage, thus demonstrating the specificity of the chalone like effect of cartilage crude extract for endothelial cells.

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