𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Bumetanide and furosemide inhibited vascular endothelial cell proliferation

✍ Scribed by Rivka Panet; Miriam Markus; Henri Atlan

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
738 KB
Volume
158
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

il-9 1 720 krael

In this study, we examined the role of the bumetanide-sensitive Na+/K+/CIcotransport in the mitogenic signal of vascular endothelial cell proliferation. The activity of the Na+/K+/CI-cotransport is dramatically decreased in quiescent subconfluent cells, as compared to subconfluent cells growing in the presence of FGF. The Na+/K+/CI-cotransport activity of quiescent subconfluent cultures deprived of FGF decreased to 6%, whereas that of quiescent cells grown to confluency was reduced to only 33% of the activity of subconfluent cells growing in the presence of FGF. The basal low activity of Na+/K+/Cl-cotransport in the quiescent subconfluent vascular endothelial cells was dramatically stimulated by FGF. In order to explore the role of the Na+/K+/CI-cotransport in the mitogenic signal of the endothelial cells, the effect of two specific inhibitors of the cotransport -furosemide and -bumetanide was tested on cell proliferation induced by FGF. Bumetanide and furosemide inhibited synchronized cell proliferation measured by direct counting of cells and by DNA synthesis. Inhibition by fuorsemide

πŸ“œ SIMILAR VOLUMES

Inhibition of human vascular endothelial
Inhibition of human vascular endothelial cells proliferation by terbinafine
✍ Pei-Yin Ho; Yu-Chih Liang; Yuan-Soon Ho; Chiung-Tong Chen; Wen-Sen Lee πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 586 KB

## Abstract We have demonstrated previously that terbinafine (TB), an oral antifungal agent used in the treatment of superficial mycosis, suppresses proliferation of various cultured human cancer cells __in vitro__ and __in vivo__ by inhibiting DNA synthesis and activating apoptosis. In our study,

Control of proliferation of bovine vascu
Control of proliferation of bovine vascular endothelial cells
✍ Denis Gospodarowicz; John S. Moran; Debra L. Braun πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 630 KB

## Abstract The effects of Fibroblast Growth Factor (FGF) and Epidermal Growth Factor (EGF) on the proliferation of bovine vascular endothelial cells has been examined. FGF induces the initiation of DNA synthesis and cell proliferation in cloned endothelial cells of fetal and adult origin at concen

Doxazosin inhibits human vascular endoth
Doxazosin inhibits human vascular endothelial cell adhesion, migration, and invasion
✍ Kaspar Keledjian; Jason B. Garrison; Natasha Kyprianou πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 578 KB

The quinazoline-derived alpha1-adrenoceptor antagonists, doxazosin and terazosin have been recently shown to induce an anoikis effect in human prostate cancer cells and to suppress prostate tumor vascularity in clinical specimens [Keledjian and Kyprianou, 2003]. This study sought to examine the abil

Human endothelial cell attachment and pr
Human endothelial cell attachment and proliferation on a novel vascular graft prototype
✍ Knetsch, Menno L. W. ;Aldenhoff, Yvette B. J. ;Schraven, Martijn ;Koole, Leo H. πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 414 KB

## Abstract A new vascular prosthesis prototype was assessed for its ability to support an endothelial cell layer __in vitro__. A coiled tubular structure, constructed from polymer‐coated metallic wires, with an internal diameter of 690 ΞΌm, was used. Addition of heparin to the surface coating of th