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Control of organ-specific autoimmunity by immunoregulatory CD4+CD25+ T cells

✍ Scribed by Rebecca S. McHugh; Ethan M. Shevach; Angela M. Thornton


Book ID
108488949
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
143 KB
Volume
3
Category
Article
ISSN
1286-4579

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CD4+CD25+ T cells as immunoregulatory T
✍ Jian-Guo Chai; Julia Y. S. Tsang; Robert Lechler; Elizabeth Simpson; Julian Dyso πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 482 KB πŸ‘ 2 views

We have further characterized the in vitro phenotype and function of anergic and suppressive CD4(+)25(+) T cells. Following TCR ligation, DO.11.10 CD4(+)25(+) T cells suppress the activation of OT-1 CD8(+)25(-) T cells in an antigen nonspecific manner. Although suppression was seen when using a mixt