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Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia

✍ Scribed by Sachs, Leo

Book ID
109710338
Publisher
Nature Publishing Group
Year
1978
Tongue
English
Weight
633 KB
Volume
274
Category
Article
ISSN
0028-0836

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Control of normal differentiation of mye
Control of normal differentiation of myeloid leukemic cells. XII. Isolation of normal myeloid colony-forming cells from bone marrow and the sequence of differentiation to mature granulocytes in normal and D+ myeloid leukemic cells
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## Abstract An enriched population of early myeloid cells has been obtained from normal mouse bone marrow by injection of mice with sodium caseinate and the removal of cells with C3 (EAC) rosettes by Ficoll‐Hypaque density centrifugation. This enriched population had no EAC or Fc (EA) rosettes and

Control of normal differentiation of mye
Control of normal differentiation of myeloid leukemic cells. V. Normal differentiation in aneuploid leukemic cells and the chromosome banding pattern of D+ and Dβˆ’ clones
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## Abstract A line of mouse myeloid leukemic cells in culture contained two types of clones. One type can be induced by the differentiation‐inducing protein MGI to undergo normal differentiation to mature macrophages and granulocytes (D^+^ clones), whereas the other type could not be induced to dif

Control of normal differentiation of mye
Control of normal differentiation of myeloid leukemic cells. XI. Induction of a specific requirement for cell viability and growth during the differentiation of myeloid leukemic cells
✍ Eitan Fibach; Leo Sachs πŸ“‚ Article πŸ“… 1976 πŸ› John Wiley and Sons 🌐 English βš– 532 KB

## Abstract Normal hematopoietic cells require the presence of a protein (MGI) in the appropriate conditioned medium (CM) for cell viability and growth and for differentiation to mature macrophages and granulocytes. Clones of myeloid leukemic cells have been established in culture (D^+^ clones) whi

Control of normal differentiation of mye
Control of normal differentiation of myeloid leukemic cells. VI. Inhibition of cell multiplication and the formation of macrophages
✍ Joseph Lotem; Leo Sachs πŸ“‚ Article πŸ“… 1975 πŸ› John Wiley and Sons 🌐 English βš– 541 KB

## Abstract D^+^ but not D^βˆ’^ myeloid leukemic cells can be induced by the appropriate conditioned medium or by serum from endotoxin treated mice, to undergo cell migration in agar, cell attachment to the surface of a Petri dish and differentiation to mature macrophages and granulocytes. Inhibition

Control of normal differentiation of mye
Control of normal differentiation of myeloid leukemic cells. VIII. Induction of differentiation to mature granulocytes in mass culture
✍ Eitan Fibach; Leo Sachs πŸ“‚ Article πŸ“… 1975 πŸ› John Wiley and Sons 🌐 English βš– 741 KB

## Abstract There are three types of myeloid leukemic cells, IR^+^D^+^, IR^+^D^βˆ’^ and IR^βˆ’^D^βˆ’^. IR^+^D^+^ cells were induced to differentiate to granulocytes in mass culture in liquid medium by conditioned medium (CM) from cultures of lungs from mice injected with endotoxin. About 90% of the leuke