Control of myeloid differentiation and survival by Stats
β Scribed by Smithgall, Thomas E; Briggs, Scott D; Schreiner, Steven; Lerner, Edwina C; Cheng, Haiyun; Wilson, Matthew B
- Book ID
- 110062816
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 133 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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## Abstract It is shown that a 5βday schedule of two injections per day of the myeloid differentiationβinducing protein MGIβ2 inhibited the __in vivo__ development of leukemia in SL and SJL/J mice with different syngeneic MGI^+^D^+^ clones of myeloid leukemic cells. With this schedule of treatment
## Abstract Sera from different strains of mice injected with endotoxin induced clones (D^+^) from a cultured line of myeloid leukemic cells to undergo normal differentiation to mature granulocytes and macrophages. Other clones (D^β^) derived from the same cell line were not inducible by these sera
## Abstract There are clones of myeloid leukemic cells that can be induced to differentiate by the normal differentiationβinducing protein MGI to form Fc and C3 rosettes, mature macrophages and granulocytes. One of these clones (MGI^+^DMSO^+^) was also inducible by dimethylsulfoxide (DMSO) for C3 b