Control of mitogen-induced lymphocyte activation: I. The effect of cyclic AMP on DNA and RNA synthesis in PHA-stimulated cells
β Scribed by David R. Webb; Daniel P. Stites; Janice D. Perlman; Kathryn E. Austin; H.Hugh Fudenberg
- Book ID
- 118373087
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- English
- Weight
- 693 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1090-2341
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## Abstract Purified parathyroid hormone (PTH) strongly stimulates the initiation of deoxyribonucleic acid (DNA) synthesis and thereby raises the flow of cells into mitosis in rat thymic lymphocyte populations maintained __in vitro__. These actions of PTH are potentiated by caffeine and inhibited b
The possible involvement of DNA topoisomerase I in cell transition from C , to G , and in progression through the cell cycle was studied by estimating the ability of human peripheral blood lymphocytes to undergo mitogenic stimulation in the presence of the topoisomerase I inhibitor camptothecin (CAM