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Control of mitochondrial activity by miRNAs

✍ Scribed by Peifeng Li; Jianqing Jiao; Guifeng Gao; Bellur S. Prabhakar

Book ID: 102301860
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 309 KB
Volume: 113
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.24004

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✦ Synopsis

Abstract

Mitochondria supply energy for physiological function and they participate in the regulation of other cellular events including apoptosis, calcium homeostasis, and production of reactive oxygen species. Thus, mitochondria play a critical role in the cells. However, dysfunction of mitochondria is related to a variety of pathological processes and diseases. MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22 nucleotides long, and they can bind to the 3′‐untranslated region (3′‐UTR) of mRNAs, thereby inhibiting mRNA translation or promoting mRNA degradation. We summarize the molecular regulation of mitochondrial metabolism, structure, and function by miRNAs. Modulation of miRNAs levels may provide a new therapeutic approach for the treatment of mitochondria‐related diseases. J. Cell. Biochem. 113: 1104–1110, 2012. © 2011 Wiley Periodicals, Inc.

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