## Abstract Proteolytic cleavage of extracellular matrix (ECM) is a critical regulator of many physiological and pathological events. It affects fundamental processes such as cell growth, differentiation, apoptosis and migration. Most proteases are produced as inactive proenzymes that undergo prote
miRNA control of tumor cell invasion and metastasis
β Scribed by Somesh Baranwal; Suresh K. Alahari
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- French
- Weight
- 281 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0020-7136
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β¦ Synopsis
Abstract
MicroRNAs have emerged as a novel class of noncoding RNAs that regulate gene expression at the postβtranslational level in almost every biological event. A large body of evidence indicates that microRNAs regulate the expression of different genes that play an important role in cancer cell invasion, migration and metastasis. In this review, we briefly describe the role of various miRNAs in invasion, migration and metastasis which are essential steps during cancer progression.
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