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Control of diastereoselectivity in the aldolization of methyl phenylacetate

✍ Scribed by Sergio Pinheiro; Marcelo B Lima; Clara B.S.S Gonçalves; Sérgio F Pedraza; Florence M.C de Farias

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
92 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The aldolization of methyl phenylacetate with benzaldehyde in several conditions was studied. While the use of LDA in THF-HMPA gave the anti-aldol, the dibutylboron triflate furnished the syn-aldol in high diastereoselectivity (syn:anti=97:3).

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