Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: Role of the cytoskeleton
β Scribed by Marcelo G. Roma; Piotr Milkiewicz; Elwyn Elias; Roger Coleman
- Book ID
- 111721234
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 518 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0270-9139
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Isolated rat hepatocyte couplets were used to study the effect of S-adenosyl-L methionine (SAMe) treatment on disruption of canalicular function caused by cyclosporin A (CyA). Canalicular function was assessed by counting the percentage of couplets that were able to accumulate the fluorescent cholep
In contrast to organic anions, substrates for the canalicular mdr1a and b are usually organic cations and are often sequestered in high concentrations in intracellular acidic compartments. Because many of these compounds are therapeutic agents, we investigated if their sequestration could be regulat