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Contribution of the P51 subunit of HIV-1 reverse transcriptase to enzyme processivity

โœ Scribed by S.C. Huang; J.R. Smith; L.K. Moen

Book ID
115765047
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
442 KB
Volume
184
Category
Article
ISSN
0006-291X

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Site-directed mutagenesis has demonstrated that changes within the human immunodeficiency virus reverse transcriptase coding sequence alone can account for viral resistance to inhibitors. Inhibitor sensitivity of mutant enzymes in vitro correlates with the sensitivity of the virus to non-nucleoside