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Contribution of the interleukin-1β gene polymorphism in multiple system atrophy

✍ Scribed by Masataka Nishimura; Hideshi Kawakami; Osamu Komure; Hirofumi Maruyama; Hiroyuki Morino; Yuishin Izumi; Shigenobu Nakamura; Ryuji Kaji; Sadako Kuno

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
60 KB
Volume
17
Category
Article
ISSN
0885-3185

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✦ Synopsis

We studied genetic polymorphisms in the promoter region at position -511 of the interleukin (IL) -1beta gene (IL-1B-511) and at position -889 of the IL-1alpha gene (IL-1A-889), in 111 Japanese patients with multiple system atrophy (MSA) and 160 controls. The distribution of IL-1B-511 was significantly different between MSA patients and controls, because of the under-representation of patients with homozygotes for allele 2 (IL-1B-511*2), a high producer of IL-1beta. The frequency of IL-1A-889*2, a high secretor of IL-1alpha, was also decreased in MSA patients. Our findings suggest that abnormal cytokine expression may be implicated in the pathogenesis of MSA.

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