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Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment

✍ Scribed by Mohammad-Reza Shiran; Martin S. Lennard; Mohammad-Zafar Iqbal; Oldwale Lagundoye; Nicholas Seivewright; Geoffrey T. Tucker; Amin Rostami-Hodjegan

Book ID
108642211
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
660 KB
Volume
67
Category
Article
ISSN
0306-5251

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A validated SIM GC/MS method for the sim
A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study
✍ Marios Spanakis; Ioannis S. Vizirianakis; Maria Mironidou-Tzouveleki; Ioannis Ni πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 347 KB πŸ‘ 2 views

## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, i