✦ LIBER ✦

Contribution of IL23R but not ATG16L1 to Crohn's disease susceptibility in Koreans

✍ Scribed by Suk-Kyun Yang; Miseon Park; Jiyoung Lim; Sang Hyoung Park; Byong Duk Ye; Inchul Lee; Kyuyoung Song

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 89 KB
Volume: 15
Category: Article
ISSN: 1078-0998
DOI: 10.1002/ibd.20921

No coin nor oath required. For personal study only.

✦ Synopsis

Background: Recent genome-wide association studies in Caucasian populations identified IL23R and ATG16L1 as susceptibility genes to Crohn's disease (CD). We tested 5 IL23R single nucleotide polymorphisms (SNPs) and 12 ATG16L1 SNPs in Korean patients to determine whether these genes are associated with susceptibility to CD in a non-Caucasian population.

Methods:

We analyzed 5 IL23R SNPs and 12 ATG16L1 SNPs in 380 patients with CD and 380 healthy controls.

Results: Two IL23R gene variants, an intronic SNP rs1004819 and intergenic SNP rs1495465, showed significant associations with CD; the adjusted odds ratio (aOR) for rs1004819 was 1.822 (95% confidence interval [CI] ϭ 1.164 -2.852, P ϭ 0.009) and aOR for rs1495965 was 1.650 (95% CI ϭ 1.102-2.471, P ϭ 0.015). The genotype-phenotype analysis showed subphenotype specificity to stricturing and penetrating behaviors. On the other hand, none of the 12 ATG16L1 SNPs showed any positive association with CD in Koreans. The contribution of IL23R variants in Korean CD patients overall is low in comparison with studies of Caucasian.

Conclusions:

Our data in Koreans support the previous Caucasian reports of an association of the IL23R gene with CD.

📜 SIMILAR VOLUMES

ATG16L1 contribution to Crohn's disease

ATG16L1 contribution to Crohn's disease risk in Sicily

✍ Ruggeri Rosario Fabio; Renda Maria Concetta; Civitavecchia Giuseppe; Renna Sara; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 49 KB

Autophagy gene ATG16L1 influences suscep

Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe

✍ J. Van Limbergen; R.K. Russell; E.R. Nimmo; H.E. Drummond; L. Smith; N.H. Anders 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB 👁 2 views

## Background: The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults. Our aim was to assess whether germline variation of ATG16L1 acts as an independent determinant of susceptibility to childhood-onset CD in the high-incidence S

Autophagy gene ATG16L1 but not IRGM is a

Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children

✍ Devendra K. Amre; David R. Mack; Kenneth Morgan; Alfreda Krupoves; Irina Costea; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB 👁 1 views

Background: Recent genome-wide studies have implicated the autophagy genes ATG16L1 and IRGM in the pathogenesis of Crohn's disease (CD). We investigated whether these genes were associated with CD in Canadian children. ## Methods: A case-control study was carried out at 2 pediatric gastroenterolog

CARD15 and IL23R influences Crohn's dise

CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population

✍ Márcia Luiza Baptista; Heda Amarante; Geraldo Picheth; Vera Lucia Sdepanian; Nic 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB

## Background: Although many genetic variants are identified in association with crohn's disease (cd), card15, il23r, and atg16l1 association with cd have been firmly confirmed in caucasians of european ancestry. the prevalence of cd is rapidly rising in brazil, where european ancestry is firmly ad

Contributions of IBD5, IL23R, ATG16L1, a

Contributions of IBD5, IL23R, ATG16L1, and NOD2 to Crohn's disease risk in a population-based case-control study: Evidence of gene–gene interactions

✍ Toshihiko Okazaki; Ming-Hsi Wang; Patricia Rawsthorne; Michael Sargent; Lisa Wu 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB

Background: IBD5, IL23R, and ATG16L1 genetic variations are established Crohn's disease (CD) risks alleles. We evaluated these in a population-based case-control study within a cohort to determine their penetrance, population attributable risk, independence, and relationship to other established CD

Contribution of TNFSF15 gene variants to

Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population

✍ Mark Tremelling; Carlo Berzuini; Dunecan Massey; Francesca Bredin; Catherine Pri 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 83 KB

Background: Identification of Crohn's disease (CD)-associated genetic variants is key to understanding pathogenic pathways underlying disease susceptibility. Recent reports of an association between TNFSF15 variants and CD have been modestly replicated in European populations, suggesting heterogenei