𝔖 Bobbio Scriptorium
✦   LIBER   ✦

CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population

✍ Scribed by Márcia Luiza Baptista; Heda Amarante; Geraldo Picheth; Vera Lucia Sdepanian; Nicholas Peterson; Umesh Babasukumar; Hermênio C. Lima; Subra Kugathasan

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
90 KB
Volume
14
Category
Article
ISSN
1078-0998

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

Although many genetic variants are identified in association with crohn's disease (cd), card15, il23r, and atg16l1 association with cd have been firmly confirmed in caucasians of european ancestry. the prevalence of cd is rapidly rising in brazil, where european ancestry is firmly admixed with natives and africans, resulting in a heterogeneous population. we investigated the contribution of card15, il23r, and atg16l1 with cd risk in a heterogeneous brazilian population.

Methods:

Genotyping for card15 (r702w, g908r, 3020insc), il23r (rs1004819, rs7517847, rs11209026, rs10889677, rs1495965), and atg16l1 (rs2241880) was performed in 187 children and adults with cd and 255 healthy ethnically matched controls. clinical records were systematically reviewed and detailed phenotypic information was obtained.

Results:

At least 1 card15 risk allele was present in 30% of the cd patients compared with 10% of controls. variants of card15 (3020insc and r702w) and il23r (rs1004819, rs11209026, and rs1088967) were associated with cd. however, no genotype-phenotype correlations were found among the brazilian cd population with card15 or il23r variants. no significant association was achieved with atg16l1.

Conclusions:

Card15 and il23r confer susceptibility to cd in the brazilian population. however, the presence of these variants did not influence disease phenotype. further research should be focused on larger sample sizes with population admixture analysis to better understand the risks and genotype-phenotype correlation in populations like brazil where the prevalence of cd is rapidly rising.

📜 SIMILAR VOLUMES

Contribution of IL23R but not ATG16L1 to
Contribution of IL23R but not ATG16L1 to Crohn's disease susceptibility in Koreans
✍ Suk-Kyun Yang; Miseon Park; Jiyoung Lim; Sang Hyoung Park; Byong Duk Ye; Inchul 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB 👁 1 views

Background: Recent genome-wide association studies in Caucasian populations identified IL23R and ATG16L1 as susceptibility genes to Crohn's disease (CD). We tested 5 IL23R single nucleotide polymorphisms (SNPs) and 12 ATG16L1 SNPs in Korean patients to determine whether these genes are associated wi

Autophagy gene ATG16L1 influences suscep
Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe
✍ J. Van Limbergen; R.K. Russell; E.R. Nimmo; H.E. Drummond; L. Smith; N.H. Anders 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB 👁 2 views

## Background: The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults. Our aim was to assess whether germline variation of ATG16L1 acts as an independent determinant of susceptibility to childhood-onset CD in the high-incidence S

Seroreactivity to microbial components i
Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients
✍ Maria Papp; Istvan Altorjay; Gary L. Norman; Zakera Shums; Karoly Palatka; Zsuzs 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB 👁 2 views

Background: Antibodies directed against Saccharomyces cerevisiae (ASCA), perinuclear components of neutrophils (pANCA), and porin protein C of Escherichia coli (anti-OmpC) are reported to be associated with disease phenotype and may be of diagnostic importance in inflammatory bowel disease (IBD). Si

Contributions of IBD5, IL23R, ATG16L1, a
Contributions of IBD5, IL23R, ATG16L1, and NOD2 to Crohn's disease risk in a population-based case-control study: Evidence of gene–gene interactions
✍ Toshihiko Okazaki; Ming-Hsi Wang; Patricia Rawsthorne; Michael Sargent; Lisa Wu 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB 👁 1 views

Background: IBD5, IL23R, and ATG16L1 genetic variations are established Crohn's disease (CD) risks alleles. We evaluated these in a population-based case-control study within a cohort to determine their penetrance, population attributable risk, independence, and relationship to other established CD