## Abstract ## Objective To investigate whether protease‐activated receptor 1 (PAR‐1) and/or PAR‐2 promotes the invasiveness/proliferation of synovial fibroblasts (SFs) and to determine the signaling mechanisms of these pathways. ## Methods SFs were isolated from the synovial tissue of patients
✦ LIBER ✦
Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis
✍ Scribed by Eric Hyun; Patricia Andrade-Gordon; Martin Steinhoff; Paul L. Beck; Nathalie Vergnolle
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 2010
- Tongue
- English
- Weight
- 506 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1420-908X
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## Abstract This study investigated the combined application of Transforming Growth Factor β‐1 (TGFβ‐1) and Bone Morphogenetic Protein‐2 (BMP‐2) to stimulate osteogenic expression __in vitro__. TGFβ‐1 and BMP‐2 fulfill specific roles in the formation of new bone. COLLOSS® E, a bone‐derived collagen