✦ LIBER ✦

Contrast-enhanced sonography in the diagnosis of small hepatocellular carcinoma ≤2 cm

✍ Scribed by Hui-Xiong Xu; Xiao-Yan Xie; Ming-De Lu; Guang-Jian Liu; Zuo-Feng Xu; Yan-Lin Zheng; Jin-Yu Liang; Li-Da Chen

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 384 KB
Volume: 36
Category: Article
ISSN: 0091-2751
DOI: 10.1002/jcu.20433

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To evaluate the usefulness of contrast‐enhanced sonography (CEUS) in the diagnosis of small hepatocellular carcinoma (HCC) measuring ≤2 cm in diameter.

Methods

We identified 104 focal liver lesions measuring ≤2 cm in 104 consecutive patients who were enrolled for baseline sonography (BUS) and CEUS examination (49 HCCs, 55 non‐HCCs). A real‐time, contrast‐specific mode of contrast pulse sequencing and a sulphur hexafluoride‐filled microbubble contrast agent were used for CEUS. The diagnostic performances of BUS and CEUS in differentiating focal liver lesions (HCC or non‐HCC) were analyzed and compared.

Results

On CEUS, 43 (87.8%) of the 49 HCC lesions were hyperenhanced, 5 (10.2%) were isoenhanced, and 1 (2%) was hypoenhanced during the arterial phase when compared with adjacent liver tissue. Thirty‐nine (79.6%) HCCs exhibited washout from the portal phase to the late phase. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy before and after contrast agent administration were 28.6% (14/49) versus 79.6% (39/49) (p < 0.001), 94.5% (52/55) versus 92.7% (51/55) (p > 0.05), 82.4% (14/17) versus 90.7% (39/43) (p > 0.05), 59.8% (52/87) versus 90.7% (39/43) (p < 0.01), and 63.5% (66/104) versus 86.5% (90/104) (p < 0.001), respectively. No significant difference in diagnostic performance of CEUS was found between lesions measuring ≤1.5 cm and those 1.6–2 cm and between lesions located at a depth of ≤6 cm from the skin and those located deeper.

Conclusions

📜 SIMILAR VOLUMES

Contrast-enhanced sonography with abdomi

Contrast-enhanced sonography with abdominal virtual sonography in monitoring radiofrequency ablation of hepatocellular carcinoma

✍ Yoshiyasu Kisaka; Masashi Hirooka; Yohei Koizumi; Masanori Abe; Bunzo Matsuura; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB

## Abstract ## __Background.__ Contrast‐enhanced CT is regarded as the gold standard for monitoring radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). Recently, 3‐dimensional volume data from CT have been used to create cross‐sectional multiplanar reconstruction images. Using this te

Flash-echo contrast sonography in the ev

Flash-echo contrast sonography in the evaluation of response of small hepatocellular carcinoma to percutaneous ablation

✍ Jing-Houng Wang; Sheng-Nan Lu; Hung-Da Tung; Chi-Sin Changchien; Chao-Hung Hung; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 472 KB

## Abstract ## **__Purpose.__** To evaluate the use of flash‐echo contrast sonography (FECS) in subtraction mode in assessing small hepatocellular carcinoma (HCC) after percutaneous local ablation therapy. ## **__Methods.__** Between March 2000 and February 2002, we prospectively assessed small

Contrast-enhanced sonography in the diag

Contrast-enhanced sonography in the diagnosis of acute mesenteric ischemia: Case report

✍ Andrea Giannetti; Marco Biscontri; Paola Randisi; Bernardo Cortese; Chiara Minac 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 288 KB

## Abstract Acute mesenteric ischemia is a serious condition associated with high mortality. Multislice CT and magnetic resonance angiography have proved accurate in diagnosing this pathology, which requires a prompt diagnosis to start appropriate therapy. We report the case of an 87‐year‐old woman

Value of contrast-enhanced color Doppler

Value of contrast-enhanced color Doppler sonography in diagnosing hepatocellular carcinoma with special attention to the “color-filled pattern”

✍ Tanaka, Sachiko; Kitamra, Tsugio; Fujita, Makoto; Yoshioka, Fumi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 543 KB

Purpose. The purpose of this study is to evaluate the effectiveness of contrast-enhanced color Doppler sonography in the diagnosis of hepatocellular carcinoma (HCC), with special attention to the value of a ''color-filled pattern.'' Methods. Contrast enhancement with Levovist was performed on 30 liv

Contrast-enhanced power Doppler sonograp

Contrast-enhanced power Doppler sonography and helical computed tomography for assessment of vascularity of small hepatocellular carcinomas before and after percutaneous ablation

✍ Ramon Vilana; Josep M. Llovet; Luis Bianchi; Marcelo Sanchez; Mario Pagés; Marga 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB

## Purpose: We compared the usefulness of levovist-enhanced power doppler imaging (pdi) and helical ct in the depiction of tumor vascularity before and after percutaneous ablation of small hepatocellular carcinomas (hccs). ## Methods: Thirty-one cirrhotic patients with solitary unresectable hccs

Significance of telomerase activity in t

Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinoma

✍ Ryo Nakashio; Mikiya Kitamoto; Hidetoshi Tahara; Toshio Nakanishi; Toshinori Ide 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 243 KB 👁 2 views

Precise diagnosis of well-differentiated hepatocellular carcinoma (HCC) is sometimes difficult to establish. Telomerase activity was examined by telomeric-repeat-amplification protocol (TRAP) in 37 HCC nodules smaller than 3 cm in diameter, including 24 fine-needle-aspiration biopsy specimens, 22 no