Contraction of collagen lattices by cells from Dupuytren's nodules
✍ Scribed by E. Tarpila; M.R. Ghassemifar; S. Wingren; M. Ågren; L. Franzén
- Book ID
- 117437345
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 797 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0363-5023
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A range of dermatologically useful drugs were added to human skin fibroblasts cultured in collagen lattices to assess possible effects on the rate of lattice contraction. Vitamin C, Vitamin E, phenytoin, sodium salicylate, o-penicillamine and dibutyryl c-AMP had no significant effect. Chiorhexidine
## Abstract Fibroblast‐populated collagen lattices (FPCL), prepared in petri dishes with serum‐containing culture medium and incubated at 37°C, undergo progressive and symmetric contraction (reduction in size) over a period of days. The in vitro contraction process requires viable cells with intact