Epac1-induced cellular proliferation in
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Uma Kant Misra; Salvatore Vincent Pizzo
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Article
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2009
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John Wiley and Sons
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English
β 524 KB
## Abstract cAMPβdependent, PKAβindependent effects on cell proliferation are mediated by cAMP binding to EPAC and activation of Rap signaling. In this report, we employed the analogue 8βCPTβ2βOβMeβcAMP to study binding to EPAC and subsequent activation of BβRaf/ERK and mTOR signaling in human canc