A method for purification of commercial preparations of NADP+ from AMP contamination is described. The purification procedure includes one-step anion-exchange chromatography on Dowex-1 (formate) and results in a highly purified salt-free coenzyme with a yield of 70-8096. The chromatography condition
Contaminants in commercial dapsone
β Scribed by Andrew P. Cheung; Peter Lim
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 380 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
β¦ Synopsis
Three contaminants commonly found in commercial dapsone were identified as 2,4'-sulfonylbis(benzeneamine), 4-(phenylsulfonyl)benzeneamine, and 4-(4'-chlorophenylsulfonyl)benzeneamine. The identities were based on the spectral analysis and unambiguous synthesis of each compound. Solvent-free, pure dapsone was prepared by recrystallization from chloroform.
π SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
Chromatographic and fluorometric procedures were developed to isolate and quantitate small amounts of 2,4'-diaminodiphenyl sulfone and 4-aminodiphenyl sulfone in pharmaceutical preparations of the antileprosy drug 4,4'-diaminodiphenyl sulfone (dapsone). Identification was accomplished by comparison